Article
Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae.
Nature communications - 18 Jan 2022
Eskenazi Anaïs, Lood Cédric, Wubbolts Julia, Hites Maya, Balarjishvili Nana, Leshkasheli Lika, Askilashvili Lia, Kvachadze Leila, van Noort Vera, Wagemans Jeroen, Jayankura Marc, Chanishvili Nina, de Boer Mark, Nibbering Peter, Kutateladze Mzia, Lavigne Rob, Merabishvili Maya, Pirnay Jean-Paul
Abstract excerpt
A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient's wounds and overall condition. In...
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