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Article

Associations among locus coeruleus catecholamines, tau pathology, and memory in aging

15 Jan 2022

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35034099
DOI: 10.1038/s41386-022-01269-6

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Associations among locus coeruleus catecholamines, tau pathology, and memory in agingPMID 35034099Read ↗

Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer’s diseaseSemantic proximity Read ↗

Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s diseaseSemantic proximity Read ↗

Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's diseaseSemantic proximity Read ↗

Alzheimer's disease-like pathology-triggered oxidative stress, alterations in monoamines levels, and structural damage of locus coeruleus neurons are partially recovered by a mix of proteoglycans of embryonic genesisSemantic proximity Read ↗

Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyleSemantic proximity Read ↗

Monoaminergic neuropathology in Alzheimer’s diseaseSemantic proximity Read ↗

Locus coeruleus vulnerability to tau hyperphosphorylation in a rat modelSemantic proximity Read ↗

Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic MiceSemantic proximity Read ↗

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleusSemantic proximity Read ↗

Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrumSemantic proximity Read ↗

Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s diseaseSemantic proximity Read ↗

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