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Article

Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review.

Reviews in endocrine & metabolic disorders - 1 Feb 2022

Camastra Stefania, Ferrannini Ele

Abstract excerpt

It is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication. First, white adipose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35031911
DOI: 10.1007/s11154-021-09708-3
PMCID: PMC8873050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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