Article
Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy.
Biochemistry - 1 Feb 2022
Gavrilov Yulian, Kümmerer Felix, Orioli Simone, Prestel Andreas, Lindorff-Larsen Kresten, Teilum Kaare
Abstract excerpt
The conformational heterogeneity of a folded protein can affect not only its function but also stability and folding. We recently discovered and characterized a stabilized double mutant (L49I/I57V) of the protein CI2 and showed that state-of-the-art prediction methods could not predict the increased stability relative to the wild-type protein. Here, we have examined whether changed native-state dynamics, and...
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