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Article

Endothelial-derived extracellular microRNA-92a promotes arterial stiffness by regulating phenotype changes of vascular smooth muscle cells.

Scientific reports - 10 Jan 2022

Wang Chen, Wu Haoyu, Xing Yuanming, Ye Yulan, He Fangzhou, Yin Qian, Li Yujin, Shang Fenqing, Shyy John Y-J, Yuan Zu-Yi

Abstract excerpt

Endothelial dysfunction and vascular smooth muscle cell (VSMC) plasticity are critically involved in the pathogenesis of hypertension and arterial stiffness. MicroRNAs can mediate the cellular communication between vascular endothelial cells (ECs) and neighboring cells. Here, we investigated the role of endothelial-derived extracellular microRNA-92a (miR-92a) in promoting arterial stiffness by regulating EC-VSMC...

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Identifiers

PMID: 35013491
DOI: 10.1038/s41598-021-04341-1
PMCID: PMC8748448

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