Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the Topoisomerase II Alpha (TOP2A) Gene in Lung Adenocarcinoma Cells and the Association with Patient Outcomes

27 Dec 2020

Abstract excerpt

BACKGROUND This study was carried out to analyze TOP2A expression in lung adenocarcinoma (LUAD) and to assess its value in clinical diagnosis and prognosis. MATERIAL AND METHODS The Cancer Genome Atlas (TCGA) database was used to study the relationship of TOP2A expression with the progression and prognosis of LUAD. For a further elucidation of the value of TOP2A in LUAD, the effect of TOP2A knockout on cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Research Studies
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33361736
DOI: 10.12659/msm.929120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the Topoisomerase II Alpha (TOP2A) Gene in Lung Adenocarcinoma Cells and the Association with Patient OutcomesPMID 33361736Read ↗

Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha (TOP2A) in Human Malignances: A Pan-Cancer AnalysisSemantic proximity Read ↗

Prognostic significance of TOP2A in non-small cell lung cancer revealed by bioinformatic analysisSemantic proximity Read ↗

The Role of TOP2A Protein Expression and Aneuploidy in NSCLCSemantic proximity Read ↗

Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samplesSemantic proximity Read ↗

The role of TOP2A in immunotherapy and Vasculogenic mimicry in non-small cell lung cancer and its potential mechanismSemantic proximity Read ↗

FOXA1 Targets NEK2 to Mediate Cisplatin Resistance in Lung Adenocarcinoma Cells by Activating DNA Damage RepairSemantic proximity Read ↗

Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan–Meier plotterSemantic proximity Read ↗

Topoisomerase IIα, rather than IIβ, is a promising target in development of anti-cancer drugsSemantic proximity Read ↗

TOP2A is a potential biomarker and promotes platinum drug resistance in ovarian cancer: a bioinformatics and experimental analysisSemantic proximity Read ↗

TOP2A Promotes Tumorigenesis of High-grade Serous Ovarian Cancer by Regulating the TGF-β/Smad PathwaySemantic proximity Read ↗

ID2 Inhibits Lung Adenocarcinoma Cell Malignant Behaviors Through Inhibiting the Activation of the PI3K/AKT/mTOR Signaling PathwaySemantic proximity Read ↗

Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.