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Article

Genetic Variation in MicroRNA-423 Promotes Proliferation, Migration, Invasion, and Chemoresistance in Breast Cancer Cells.

International journal of molecular sciences - 29 Dec 2021

Morales-Pison Sebastian, Jara Lilian, Carrasco Valentina, Gutiérrez-Vera Cristian, Reyes José Miguel, Gonzalez-Hormazabal Patricio, Carreño Leandro J, Tapia Julio C, Contreras Héctor R

Abstract excerpt

MicroRNA-423 (miR-423) is highly expressed in breast cancer (BC). Previously, our group showed that the SNP rs6505162:C>A located in the pre-miR-423 was significantly associated with increased familial BC risk in patients with a strong family history of BC. Therefore, in this study, we evaluated the functional role of rs6505162 in mammary tumorigenesis in vitro to corroborate the association of this SNP with BC...

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PMID: 35008806
DOI: 10.3390/ijms23010380
PMCID: PMC8745459

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