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Article

Extracellular matrix remodeling in anthracycline-induced cardiotoxicity: What place on the pedestal?

International journal of cardiology - 1 Mar 2022

Grakova Elena V, Shilov Sergey N, Kopeva Kristina V, Berezikova Ekaterina N, Popova Anna A, Neupokoeva Maria N, Ratushnyak Elena T, Teplyakov Alexander T

Abstract excerpt

OBJECTIVE: To evaluate the role of matrix metalloproteinases (MMP)-2 and 9 and the gene polymorphisms of MMP-2 (rs243865) and MMP-9 (rs3918242) in the course of anthracycline-induced cardiotoxicity (AIC) in women without previous cardiovascular diseases (CVD) during 24-months. METHODS: A total of 114 women (47.0 [44.0; 52.0] years old) with AIC of NYHA class I-III who received doxorubicin for breast cancer were...

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PMID: 35007649
DOI: 10.1016/j.ijcard.2022.01.013

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