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Article

Vulnerability to Meningococcal Disease in Immunodeficiency Due to a Novel Pathogenic Missense Variant in NFKB1.

Frontiers in immunology - 1 Jan 2021

Anim Manfred, Sogkas Georgios, Schmidt Gunnar, Dubrowinskaja Natalia, Witte Torsten, Schmidt Reinhold Ernst, Atschekzei Faranaz

Abstract excerpt

NF-κB1 deficiency is suggested to be the most common cause of common variable immunodeficiency (CVID). NFKB1 encodes for the p105 precursor protein of NF-κB1, which is converted into the active transcriptional subunit p50 through proteasomal processing of its C-terminal half upon stimulation and is implicated in the canonical NF-kB pathway. Rare monoallelic NFKB1 variants have been shown to cause (haplo)...

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Identifiers

PMID: 35003082
DOI: 10.3389/fimmu.2021.767188
PMCID: PMC8738076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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