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Article

High-quality gene/disease embedding in a multi-relational heterogeneous graph after a joint matrix/tensor decomposition.

Journal of biomedical informatics - 1 Feb 2022

Zhou Kaiyin, Zhang Sheng, Wang Yuxing, Cohen Kevin Bretonnel, Kim Jin-Dong, Luo Qi, Yao Xinzhi, Zhou Xingyu, Xia Jingbo

Abstract excerpt

MOTIVATION: Node embedding of biological entity network has been widely investigated for the downstream application scenarios. To embed full semantics of gene and disease, a multi-relational heterogeneous graph is considered in a scenario where uni-relation between gene/disease and other heterogeneous entities are abundant while multi-relation between gene and disease is relatively sparse. After introducing this...

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PMID: 34995810
DOI: 10.1016/j.jbi.2021.103973

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