Article
Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19.
PloS one - 1 Jan 2022
Traets Marissa J M, Nijhuis Roel H T, Morré Servaas A, Ouburg Sander, Remijn Jasper A, Blok Bastiaan A, de Laat Bas, Jong Eefje, Herder Gerarda J M, Fiolet Aernoud T L, Verweij Stephan P
Abstract excerpt
BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest with varying disease severity and mortality. Genetic predisposition influences the clinical course of infectious diseases. We investigated whether genetic polymorphisms in candidate genes ACE2, TIRAP, and factor X are associated with clinical outcomes in COVID-19. METHODS: We...
Topics
- Aged
- Angiotensin-Converting Enzyme 2
- COVID-19
- Cohort Studies
- Factor X
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Membrane Glycoproteins
- Middle Aged
- Netherlands