Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome

doi:10.3389/fgene.2020.551220

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Article

Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome

29 Sept 2020

Abstract excerpt

Objectives: In March 2020 World Health Organization declared that an infectious respiratory disease caused by a new severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 (COVID-19) became a pandemic. In our study, we have analyzed a large publicly available dataset, the Genome Aggregation Database (gnomAD), as well as a cohort of 37 Russian patients with COVID-19 to assess the influence of different classes...

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PMID: 33133145
DOI: 10.3389/fgene.2020.551220

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