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Article

The expanding role for chromatin and transcription in polyglutamine disease.

Current opinion in genetics & development - 1 Jun 2014

Mohan Ryan D, Abmayr Susan M, Workman Jerry L

Abstract excerpt

Nine genetic diseases arise from expansion of CAG repeats in seemingly unrelated genes. They are referred to as polyglutamine (polyQ) diseases due to the presence of elongated glutamine tracts in the corresponding proteins. The pathologic consequences of polyQ expansion include progressive spinal, cerebellar, and neural degeneration. These pathologies are not identical, however, suggesting that disruption of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25108806
DOI: 10.1016/j.gde.2014.06.008
PMCID: PMC4253674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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