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Article

Heterologous production of active form of beta-lytic protease by Bacillus subtilis and improvement of staphylolytic activity by protein engineering.

Microbial cell factories - 28 Dec 2021

Hioki Takahiro, Yamashita Daichi, Tohata Masatoshi, Endo Keiji, Kawahara Akihito, Okuda Mitsuyoshi

Abstract excerpt

BACKGROUND: Most of the proteases classified into the M23 family in the MEROPS database exhibit staphylolytic activity and have potential as antibacterial agents. The M23 family is further classified into two subfamilies, M23A and M23B. Proteases of the M23A subfamily are thought to lack the capacity for self-maturation by auto-processing of a propeptide, which has been a challenge in heterologous production and...

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Identifiers

PMID: 34963446
DOI: 10.1186/s12934-021-01724-x
PMCID: PMC8715609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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