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Article

Case Report : Li-Fraumeni Syndrome with Central Nervous System Tumors in Two Siblings.

BMC pediatrics - 27 Dec 2021

Fang Zishi, Su Yan, Sun Hailang, Ge Ming, Qi Zhan, Hao Chanjuan, Qian Suyun, Ma Xiaoli

Abstract excerpt

BACKGROUND: Li-Fraumeni syndrome (LFS) is a rare autosomal dominant cancer predisposition syndrome caused by germline TP53 gene mutations. It is characterized by high risk of early-onset cancer, and has been confirmed as associated with multiple tumors clinically. So pediatricians should be more alert to LFS in children with tumors. Choroid plexus carcinoma (CPC) is a rare, malignant tumor which account for less...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34961499
DOI: 10.1186/s12887-021-03070-8
PMCID: PMC8711161

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