Article
Li-Fraumeni syndrome: multiple distinct brain tumours in two brothers.
Neuro-Chirurgie - 1 Jan 2000
Lechien J R, Brotchi J, Van Maldergem L, Costa de Araujo P, Bruninx G, Hilbert P, Nubourgh Y
Abstract excerpt
Li-Fraumeni syndrome is a rare autosomal dominant cancer-prone condition characterized by the occurrence of a large set of different types of cancer in a patient and their family. A germline disease-causing mutation of the gene encoding the p53 protein is associated with the syndrome. We report on a family in which segregation of a TP53 mutation in two generations was associated with two brain tumours, a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.