Article
Development of cervical intraepithelial lesions and cervical cancer is not influenced by SOD2 RS4880 polymorhism.
Pathology, research and practice - 1 Feb 2022
Curti Rafaela Roberta de Jaime, Castilha Eliza Pizarro, Bonaldo Ana Luiza Labbate, Okuyama Nádia Calvo Martins, Trugilo Kleber Paiva, Guembarovski Roberta Losi, Couto-Filho José d'Oliveira, Watanabe Maria Angelica Ehara, de Oliveira Karen Brajão
Abstract excerpt
Some of the more than 200 known HPV types are essential for cervical cancer development, the third type of cancer most incident in the female population. However, for the malignant transformation occur, some cofactors are needed, as the reactive oxygen species (ROS), which can be neutralized by the antioxidant system. The SOD2 enzyme, encoded by the same name gene, is found in mitochondria and is part of the...
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