Article
Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele.
The American journal of pathology - 1 Mar 2022
Gal Jozsef, Katsumata Yuriko, Zhu Haining, Srinivasan Sukanya, Chen Jing, Johnson Lance Allen, Wang Wang-Xia, Golden Lesley Renee, Wilcock Donna M, Jicha Gregory A, Cykowski Matthew D, Nelson Peter Tobias
Abstract excerpt
The amygdala is vulnerable to multiple or "mixed" mis-aggregated proteins associated with neurodegenerative conditions that can manifest clinically with amnestic dementia; the amygdala region is often affected even at earliest disease stages. With the original intent of identifying novel dementia-associated proteins, the detergent-insoluble proteome was characterized from the amygdalae of 40 participants from the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.