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Article

MiR-138-5p Suppresses Cell Growth and Migration in Melanoma by Targeting Telomerase Reverse Transcriptase.

Genes - 30 Nov 2021

Tarazón Estefanía, de Unamuno Bustos Blanca, Murria Estal Rosa, Pérez Simó Gema, Sahuquillo Torralba Antonio, Simarro Javier, Palanca Suela Sarai, Botella Estrada Rafael

Abstract excerpt

Recent evidence suggests the existence of a miRNA regulatory network involving human telomerase reverse transcriptase gene (hTERT), with miR-138-5p playing a central role in many types of cancers. However, little is known about the regulation of hTERT expression by microRNA (miRNAs) in melanocytic tumors. Here, we investigated the effects of miR-138-5p in hTERT regulation in melanoma cells lines. In vitro studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Melanoma, Experimental

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Source

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Identifiers

PMID: 34946880
DOI: 10.3390/genes12121931
PMCID: PMC8701232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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