Article
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.
Science (New York, N.Y.) - 24 Dec 2021
Silva Lakmali M, Doyle Andrew D, Greenwell-Wild Teresa, Dutzan Nicolas, Tran Collin L, Abusleme Loreto, Juang Lih Jiin, Leung Jerry, Chun Elizabeth M, Lum Andrew G, Agler Cary S, Zuazo Carlos E, Sibree Megan, Jani Priyam, Kram Vardit, Martin Daniel, Moss Kevin, Lionakis Michail S, Castellino Francis J, Kastrup Christian J, Flick Matthew J, Divaris Kimon, Bugge Thomas H, Moutsopoulos Niki M
Abstract excerpt
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a critical regulator of neutrophil function at the oral mucosal barrier. We demonstrate that commensal microbiota trigger extravascular fibrin deposition in the oral mucosa. Fibrin engages neutrophils through the αMβ2 integrin receptor and activates effector functions, including the production...
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