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Article

Germline RET Leu56Met Variant Is Likely Not Causative of Multiple Endocrine Neoplasia Type 2.

Frontiers in endocrinology - 1 Jan 2021

Hansen Anna Reimer, Borgwardt Line, Rasmussen Åse Krogh, Godballe Christian, Poulsen Morten Møller, Vieira Filipe G, Mathiesen Jes Sloth, Rossing Maria

Abstract excerpt

Activating variants in the receptor tyrosine kinase REarranged during Transfection (RET) cause multiple endocrine neoplasia type 2 (MEN 2), an autosomal dominantly inherited cancer-susceptibility syndrome. The variant c.166C>A, p.Leu56Met in RET was recently reported in two patients with medullary thyroid cancer (MTC). The presence of a pheochromocytoma in one of the patients, suggested a possible pathogenic role...

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Identifiers

PMID: 34925234
DOI: 10.3389/fendo.2021.764512
PMCID: PMC8672160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline RET Leu56Met Variant Is Likely Not Causative of Multiple Endocrine Neoplasia Type 2.PMID 34925234Read ↗

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