Article
Resource and infrastructure challenges on the RESIST-2 Trial: an implementation study of drug resistance genotype-based algorithmic ART switches in HIV-2-infected adults in Senegal.
Trials - 18 Dec 2021
Raugi Dana N, Diallo Khardiata, Diallo Mouhamadou Baïla, Faye Dominique, Cisse Ousseynou, Smith Robert A, Sall Fatima, Sall El Hadji Ibrahima, Faye Khadim, Diatta Jean Philippe, Diaw Binetou, Sambou Jacques, Malomar Jean Jacques, Hawes Stephen E, Seydi Moussa, Gottlieb Geoffrey S
Abstract excerpt
BACKGROUND: Second-line treatment of HIV-2 in resource-limited settings (RLS) is complicated by a lack of controlled trial data, limited availability of HIV-2-active antiretroviral drugs, and inadequate access to drug resistance testing. We conducted an implementation trial of a dried blood spot- (DBS) based, drug resistance genotype-informed antiretroviral therapy (ART) switching algorithm for HIV-2-infected...
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