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Article

Complex patterns of protease inhibitor resistance among antiretroviral treatment-experienced HIV-2 patients from Senegal: implications for second-line therapy.

Antimicrobial agents and chemotherapy - 1 Jun 2013

Raugi Dana N, Smith Robert A, Ba Selly, Toure Macoumba, Traore Fatou, Sall Fatima, Pan Charlotte, Blankenship Lindsey, Montano Alexandra, Olson Julia, Dia Badiane Ndeye Mery, Mullins James I, Kiviat Nancy B, Hawes Stephen E, Sow Papa Salif, Gottlieb Geoffrey S

Abstract excerpt

Protease inhibitor (PI)-based antiretroviral therapy (ART) can effectively suppress HIV-2 plasma load and increase CD4 counts; however, not all PIs are equally active against HIV-2, and few data exist to support second-line therapy decisions. To identify therapeutic options for HIV-2 patients failing ART, we evaluated the frequency of PI resistance-associated amino acid changes in HIV-2 sequences from a cohort of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23571535
DOI: 10.1128/AAC.00405-13
PMCID: PMC3716120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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