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Article

Embryonic and fetal programming of physiological disorders in adulthood

1 Dec 2004

Abstract excerpt

In the past decade, data from numerous epidemiological studies have indicated strong inverse associations between birth weight and risk of coronary heart disease, hypertension, type 2-diabetes, and other diseases in adulthood. The "Barker hypothesis" thus postulates that a number of organ structures and functions undergo programming during embryonic and fetal life. This developmental programming determines the...

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PMID: 15662709
DOI: 10.1002/bdrc.20029

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