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Article

Apolipoprotein E ε4 allele impairs cortical activity in healthy aging and Alzheimer's disease.

Behavioural brain research - 26 Feb 2022

Pedroso Renata Valle, Fraga Francisco José, Nascimento Carla Manuela Crispim, Pott-Junior Henrique, Cominetti Márcia Regina

Abstract excerpt

AIM: To investigate the influence of apolipoprotein E (APOE) genotype on cortical activity, using the event-related potential P300 in healthy older adults and individuals with Alzheimer's disease (AD). METHODS: A cohort of 37 healthy older adults and 48 with AD participated in this study and completed an auditory oddball task using electroencephalographic equipment with 21 channels (10-20 system). APOE genotyping...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Case-Control Studies
Cognition
Cross-Sectional Studies
Electroencephalography
Evoked Potentials
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Healthy Aging

Humans

Male

Middle Aged

Source

Identifiers

PMID: 34871705
DOI: 10.1016/j.bbr.2021.113700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34871705-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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