Article
Mutation of a prenyltransferase results in accumulation of subglutinols and destruxins and enhanced virulence in the insect pathogen, Metarhizium anisopliae.
Environmental microbiology - 1 Mar 2022
Li Chengzhou, Huang Wenyou, Zhou Tingting, Zhao Qian, Huang Peiquan, Qi Ping, Huang Song, Huang Shuaishuai, Keyhani Nemat O, Huang Zhen
Abstract excerpt
The insect pathogenic fungus, Metarhizium anisopliae is a commercialized microbial agent used in biological control efforts targeting a diverse range of agricultural and other insect pests. The second step in the synthesis of a group of M. anisopliae α-pyrone diterpenoids (termed subglutinols) involves the activity of a prenyltransferase family geranylgeranyl diphosphate synthase (product of the subD/MaGGPPS5...
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