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Article

Isocitrate dehydrogenase mutations are associated with altered IL-1β responses in acute myeloid leukemia.

Leukemia - 1 Apr 2022

Sunthankar Kathryn I, Jenkins Matthew T, Cote Candace H, Patel Sweta B, Welner Robert S, Ferrell P Brent

Abstract excerpt

Mutations in isocitrate dehydrogenase 2 (IDH2) have been noted to impact cellular differentiation in addition to DNA and histone methylation. However, little is known about the impact of IDH2 mutations on intracellular signaling. Using an isogenic cell line model, we investigated both differentiation and signaling responses in IDH2 mutant cells and show augmented responses to inflammatory immune ligands. Using...

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Identifiers

PMID: 34857894
DOI: 10.1038/s41375-021-01487-9
PMCID: PMC9066619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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