Article
Mass spectrometric detection of KRAS protein mutations using molecular imprinting.
Nanoscale - 16 Dec 2021
Norman Rachel L, Singh Rajinder, Muskett Frederick W, Parrott Emma L, Rufini Alessandro, Langridge James I, Runau Franscois, Dennison Ashley, Shaw Jacqui A, Piletska Elena, Canfarotta Francesco, Ng Leong L, Piletsky Sergey, Jones Donald J L
Abstract excerpt
Cancer is a disease of cellular evolution where single base changes in the genetic code can have significant impact on the translation of proteins and their activity. Thus, in cancer research there is significant interest in methods that can determine mutations and identify the significant binding sites (epitopes) of antibodies to proteins in order to develop novel therapies. Nano molecularly imprinted polymers...
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