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Article

Decoding the effects of synonymous variants.

Nucleic acids research - 16 Dec 2021

Zeng Zishuo, Aptekmann Ariel A, Bromberg Yana

Abstract excerpt

Synonymous single nucleotide variants (sSNVs) are common in the human genome but are often overlooked. However, sSNVs can have significant biological impact and may lead to disease. Existing computational methods for evaluating the effect of sSNVs suffer from the lack of gold-standard training/evaluation data and exhibit over-reliance on sequence conservation signals. We developed synVep (synonymous Variant...

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Identifiers

PMID: 34850938
DOI: 10.1093/nar/gkab1159
PMCID: PMC8682775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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