Article
Plasma microRNA Interindividual Variability in Healthy Individuals, Pregnant Women, and an Individual with a Stably Altered Neuroendocrine Phenotype.
Clinical chemistry - 26 Nov 2021
Max Klaas E A, Wang Victoria R, Chang Michael S, Liau Jonathan, Weiss Zachary R, Morgan Stephanie, Li Jenny, Bogardus Kimberly A, Morozov Pavel, Suryawanshi Hemant, Akat Kemal M, Ben-Dov Iddo Z, Hurley Arlene M, Dowd Kathleen, Williams Zev, Tuschl Thomas
Abstract excerpt
BACKGROUND: Extracellular RNAs (exRNAs) in biofluids are amenable to quantitative analysis and proposed as noninvasive biomarkers for monitoring organ function. Cell-lineage-specific microRNAs (miRNAs) are present in plasma as soluble ribonucleoproteins or enclosed in exRNA carriers and transported through the vasculature. However, more extensive studies of healthy individuals are needed to gain insights into the...
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