Article
A hypomorphic allele of telomerase uncovers the minimal functional length of telomeres in Arabidopsis.
Genetics - 2 Oct 2021
Watson J Matthew, Trieb Johanna, Troestl Martina, Renfrew Kyle, Mandakova Terezie, Fulnecek Jaroslav, Shippen Dorothy E, Riha Karel
Abstract excerpt
Despite the essential requirement of telomeric DNA for genome stability, the length of telomere tracts between species substantially differs, raising the question of the minimal length of telomeric DNA necessary for proper function. Here, we address this question using a hypomorphic allele of the telomerase catalytic subunit, TERT. We show that although this construct partially restored telomerase activity to a...
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