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Article

Chronic insomnia in the setting of MTHFR polymorphism.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine - 1 Apr 2022

Kapoor Vidhi, Watson Nathaniel F, Ball Lonnele

Abstract excerpt

We present a patient with chronic insomnia resistant to traditional pharmacologic (eg, sedative-hypnotics) and nonpharmacologic (eg, cognitive behavioral therapy for insomnia) therapy. A finding of elevated serum homocysteine triggered a whole-genome sequencing analysis which revealed a homozygous methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T/C677T; dbSNP rs1801133). Interventions targeting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34847989
DOI: 10.5664/jcsm.9794
PMCID: PMC8974368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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