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Article

Personalised Nutraceutical Treatment Guided by MTHFR Genotype in Mental Health: A Retrospective Cohort Study.

Nutrients - 26 Aug 2026

Beer Cristina, Rae Fiona, Watt Mikayla, Trzaskowski Maciej, Yates Clarissa, Semmler Annalese, Voisey Joanne

Abstract excerpt

BACKGROUND & AIMS: One-carbon metabolism plays a central role in neurotransmitter synthesis, methylation capacity, and neurobiological resilience. Variants in the methylenetetrahydrofolate reductase (MTHFR) gene can reduce enzymatic activity, affecting folate- and methionine-cycle functions and potentially influencing biological pathways relevant to mood and anxiety disorders. Personalised nutraceutical treatment...

Read the complete abstract on PubMed

Topics

Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Retrospective Studies
Dietary Supplements
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

Male

Adult

Mental Health

Precision Medicine

Depression

Folic Acid

Treatment Outcome

Anxiety

Anxiety Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 42738962
DOI: 10.3390/nu18172791
PMCID: PMC13566919

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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