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Article

Developmental changes in cardiac expression of KCNQ1 and SCN5A spliceoforms: Implications for sudden unexpected infant death.

Heart rhythm - 1 Apr 2022

Williams Alexandra F, Bryan Audra F, Tomasek Kelsey, Fulmer Carlos A, Gregory Kyle, Bozeman Cole, Li Feng, Absi Tarek S, Su Yan Ru, Kannankeril Prince J

Abstract excerpt

BACKGROUND: Sudden unexpected infant death (SUID) occurs unpredictably and remains unexplained after scene investigation and autopsy. Approximately 1 in 7 cases of SUID can be related to a cardiac cause, and developmental regulation of cardiac ion channel genes may contribute to SUID. OBJECTIVE: The goal of this study was to investigate the developmental changes in the spliceoforms of SCN5A and KCNQ1, 2 genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34843966
DOI: 10.1016/j.hrthm.2021.11.031
PMCID: PMC8977237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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