Causal effects from non-alcoholic fatty liver disease on kidney function: A Mendelian randomization study.

doi:10.1111/liv.15118

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Causal effects from non-alcoholic fatty liver disease on kidney function: A Mendelian randomization study.

Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2022

Park Sehoon, Lee Soojin, Kim Yaerim, Cho Semin, Kim Kwangsoo, Chul Kim Yong, Han Seung Seok, Lee Hajeong, Lee Jung Pyo, Joo Kwon Wook, Lim Chun Soo, Kim Yon Su, Kim Dong Ki

Abstract excerpt

BACKGROUND AND AIMS: An observational association between nonalcoholic fatty liver disease (NAFLD) and kidney function impairment has been reported. We aimed to investigate the causal effects from NAFLD on estimated glomerular filtration rate (eGFR) by a Mendelian randomization (MR) study. METHODS: We first performed single-variant MR with rs738409 as a genetic instrument for NAFLD. Another genetic instrument was...

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PMID: 34843158
DOI: 10.1111/liv.15118

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