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Article

p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy.

International journal of molecular sciences - 16 Nov 2021

Kumbrink Jörg, Li Pan, Pók-Udvari Agnes, Klauschen Frederick, Kirchner Thomas, Jung Andreas

Abstract excerpt

p130 Crk-associated substrate (p130Cas) is associated with poor prognosis and treatment resistance in breast and lung cancers. To elucidate p130Cas functional and clinical role in colorectal cancer (CRC) progression/therapy resistance, we performed cell culture experiments and bioinformatic/statistical analyses of clinical data sets. p130Cas expression was associated with poor survival in the cancer genome atlas...

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Identifiers

PMID: 34830244
DOI: 10.3390/ijms222212364
PMCID: PMC8625396

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