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Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

26 Nov 2021

Abstract excerpt

The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Here, we report on the identification of amiloride-based small molecules that potently inhibit OC43 and SARS-CoV-2 replication...

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PMID: 34826236
DOI: 10.1126/sciadv.abl6096

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