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Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition

21 May 2018

Abstract excerpt

Mammalian cell perfusion cultures represent a promising alternative to the current fed-batch technology for the production of various biopharmaceuticals. Long-term operation at a fixed viable cell density (VCD) requires a viable culture and a constant removal of excessive cells. Product loss in the cell removing bleed stream deteriorates the process yield. In this study, the authors investigate the use of...

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PMID: 29781256
DOI: 10.1002/biot.201700722

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