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Analysis of Tubespins as a suitable scale‐down model of bioreactors for high cell density CHO cell culture

17 Dec 2016

Abstract excerpt

High cell density (HCD) culture increases recombinant protein productivity via higher biomass. Compared to traditional fed-batch cultures, HCD is achieved by increased nutrient availability and removal of undesired metabolic components via regular medium replenishment. HCD process development is usually performed in instrumented lab-scale bioreactors (BR) that require time and labor for setup and operation. To...

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PMID: 27977914
DOI: 10.1002/btpr.2418

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