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Article

Causal effects of atrial fibrillation on brain white and gray matter volume: a Mendelian randomization study.

BMC medicine - 24 Nov 2021

Park Sehoon, Lee Soojin, Kim Yaerim, Cho Semin, Kim Kwangsoo, Kim Yong Chul, Han Seung Seok, Lee Hajeong, Lee Jung Pyo, Lee Soryoung, Choi Eue-Keun, Joo Kwon Wook, Lim Chun Soo, Kim Yon Su, Kim Dong Ki

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) and brain volume loss are prevalent in older individuals. We aimed to assess the causal effect of atrial fibrillation on brain volume phenotypes by Mendelian randomization (MR) analysis. METHODS: The genetic instrument for AF was constructed from a previous genome-wide association study (GWAS) meta-analysis (15,993 AF patients and 113,719 controls of European ancestry). The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34814924
DOI: 10.1186/s12916-021-02152-9
PMCID: PMC8611907

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