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Article

Expression and prognostic significance of m6A-related genes in TP53-mutant non-small-cell lung cancer.

Journal of clinical laboratory analysis - 1 Jan 2022

Zhao Zhuochen, Wan Junhu, Guo Manman, Wang Yangxia, Yang Zhengwu, Zhou Fuyou, Li Zhuofang, Ming Liang

Abstract excerpt

BACKGROUND: TP53 is an important tumor suppressor gene on human 17th chromosome with its mutations more than 60% in tumor cells. Lung cancer is the highest incidence malignancy in men around the world. N-6 methylase (m6A) is an enzyme that plays an important role in mRNA splicing, translation, and stabilization. However, its role in TP53-mutant non-small-cell lung cancer (NSCLC) remains unknown. METHOD: First, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34812534
DOI: 10.1002/jcla.24118
PMCID: PMC8761469

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