Article
Precision oncology: current and future platforms for treatment selection.
Trends in cancer - 1 Sept 2024
Tang Xinran, Berger Michael F, Solit David B
Abstract excerpt
Genomic profiling of hundreds of cancer-associated genes is now a component of routine cancer care. DNA sequencing can identify mutations, mutational signatures, and structural alterations predictive of therapy response and assess for heritable cancer risk, but it has been less useful for identifying predictive biomarkers of sensitivity to cytotoxic chemotherapies, antibody drug conjugates, and immunotherapies....
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