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Article

Acute lymphoblastic leukaemia cells produce large extracellular vesicles containing organelles and an active cytoskeleton

10 Mar 2017

Abstract excerpt

ABSTRACT Extracellular vesicles have been described in non‐paracrine cellular interactions in cancer. We report a similar phenomenon in B‐cell precursor (BCP) acute lymphoblastic leukaemia (ALL). Using advanced microscopy and high throughput screening, we further characterise a subset of large vesicles (LEVs) identified in cell lines, murine models of human BCP‐ALL and clinical samples. Primary ALL blasts and...

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PMID: 28386390
DOI: 10.1080/20013078.2017.1294339

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