Article
Clinicopathologic Characteristics, Treatment Outcomes, and Acquired Resistance Patterns of Atypical EGFR Mutations and HER2 Alterations in Stage IV Non-Small-Cell Lung Cancer.
Clinical lung cancer - 1 May 2020
Patil Tejas, Mushtaq Rao, Marsh Sydney, Azelby Christine, Pujara Miheer, Davies Kurtis D, Aisner Dara L, Purcell William T, Schenk Erin L, Pacheco Jose M, Bunn Paul A, Camidge D Ross, Doebele Robert C
Abstract excerpt
BACKGROUND: The clinicopathologic characteristics, acquired resistance patterns, and outcomes among patients with atypical EGFR mutations and HER2 alterations remain underexplored. PATIENTS AND METHODS: A single-center retrospective review was conducted. Oncogenes assessed include typical EGFR (t-EGFR; exon 19 del and L858R), atypical EGFR (a-EGFR; G719X, exon 20, L861Q), HER2 (exon 19, exon 20, amplifications),...
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