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Article

Real-World Patient Characteristics, Mutational Landscape, and Outcomes in Advanced/Metastatic HER2-Mutant Non-Small Cell Lung Cancer.

JCO precision oncology - 1 Jun 2026

Lovly Christine M, Baik Christina, Nagasaka Misako, Patil Tejas, Maruti Sonia S, Stanhope Stephen, Kaya Neslihan A, Herbertz Stephan, Nordstrom Beth, Evans Kathryn, Le Xiuning

Abstract excerpt

PURPOSE: This observational study assessed the real-world characteristics, treatments, and outcomes of US patients with HER2-mutant advanced non-small cell lung cancer (NSCLC) overall and according to HER2 mutation type (tyrosine kinase domain [TKD] and non-TKD). METHODS: Deidentified data were extracted for patients with advanced/metastatic NSCLC from the Flatiron Health-Foundation Medicine NSCLC Clinico-Genomic...

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Identifiers

PMID: 42314092
DOI: 10.1200/PO-25-01272
PMCID: PMC13290063

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