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BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

19 Nov 2021

Abstract excerpt

Abstract Nicotinamide riboside (NR) is one of the orally bioavailable NAD+ precursors and has been demonstrated to exhibit beneficial effects against aging and aging-associated diseases. However, the metabolic pathway of NR in vivo is not yet fully understood. Here, we demonstrate that orally administered NR increases NAD+ level via two different pathways. In the early phase, NR was directly absorbed and...

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PMID: 34799586
DOI: 10.1038/s41467-021-27080-3

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