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Article

Zanamivir-Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses.

Journal of medicinal chemistry - 9 Dec 2021

Lv Xun, Wang Pengfei, Li Chenning, Cheng Shuihong, Bi Yuhai, Li Xuebing

Abstract excerpt

Antiviral therapy of influenza virus infections depends heavily on two viral neuraminidase (NA) inhibitors, oseltamivir (OSV) and zanamivir (ZNV). The efficacy of OSV is challenged by the development of viral resistance, while the clinical use of ZNV is limited by its poor pharmacokinetic profile and requirement for twice-daily intranasal administration. We have developed a novel NA inhibitor by conjugating ZNV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34797984
DOI: 10.1021/acs.jmedchem.1c01531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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