Article
The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum.
The American journal of psychiatry - 1 Mar 2022
Mahjani Behrang, Klei Lambertus, Mattheisen Manuel, Halvorsen Matthew W, Reichenberg Abraham, Roeder Kathryn, Pedersen Nancy L, Boberg Julia, de Schipper Elles, Bulik Cynthia M, Landén Mikael, Fundín Bengt, Mataix-Cols David, Sandin Sven, Hultman Christina M, Crowley James J, Buxbaum Joseph D, Rück Christian, Devlin Bernie, Grice Dorothy E
Abstract excerpt
OBJECTIVE: Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across the allele frequency spectrum to this heritability remains uncertain. The authors used two new homogeneous cohorts to estimate the heritability of OCD from inherited genetic variation and contrasted the results with those of previous studies. METHODS: The sample consisted of...
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