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Article

Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study

16 Nov 2021

Abstract excerpt

BACKGROUND: Hypertension and atherosclerosis may partly originate in early life. Altered epigenetic aging may be a mechanism underlying associations of early-life exposures and the development of cardiovascular risk factors in childhood. A discrepancy between chronological age and age predicted from neonatal DNA methylation data is referred to as age acceleration. It may either be positive, if DNA methylation age...

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PMID: 34784966
DOI: 10.1186/s13148-021-01193-4

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