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Epigenetic gestational age and the relationship with developmental milestones in early childhood

6 Jan 2023

Abstract excerpt

Shorter gestational age (GA) is a risk factor of developmental delay. GA is usually estimated clinically from last menstrual period and ultrasound. DNA methylation (DNAm) estimates GA using sets of cytosine-guanine-sites coupled with a clock algorithm. Therefore, DNAm-estimated GA may better reflect biological maturation. A DNAm GA greater than clinical GA, known as gestational age acceleration (GAA), may...

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PMID: 36617164
DOI: 10.1093/hmg/ddac302

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